Nevertheless, the physical substrate environment in which the cells grow remains relatively neglected. For example, rather than providing all cells with the same generic mix of nutrients, many researchers now tailor their media preparations for specific cell types. However, approaches to cell culture are starting to change. For in vitro culture, cells are procured from the human body and transferred to an artificial, minimalistic environment ill-suited to their needs.

Cells have evolved to thrive in their specific physiologic niche within the human body. Credit: STEVE GSCHMEISSNER/SCIENCE PHOTO LIBRARYД«ut donвЂ™t blame the cells - itвЂ™s how they are being cultured. (6) This process is termed angioconduction.Culturing on a 3D matrix allows cells to adopt a more typical spatial arrangement. However, if Endoformв„ў is visible, this can indicate that protease balance has been restored.Д®ndoformв„ў products also contain residual vascular channels that facilitate the rapid establishment of a dense capillary network by supporting migrating endothelial cells to establish new vasculature and a robust blood supply to help build new tissue. (4, 5) If Endoformв„ў products are not visible in the wound bed at the time of reapplication, this can indicate elevated wound protease activity. (3) Endoformв„ў products can help indicate the presence or absence of proteases and restores protease balance. (1) Endoformв„ў products only contain components found in tissue extracellular matrix.Дuring the inflammatory phase, chronic wounds are characterized by elevated wound proteases that limit healing by digesting important dermal proteins. (1, 2) Endoformв„ў products are 85% collagen and 15% important secondary molecules, including structural and adhesion proteins, and glycosaminoglycans (GAGs). Biomater Res, 23, 6 (2019) doi:10.1186/s4082-0 How It WorksД®ndoformв„ў Antimicrobial and Endoformв„ў Natural Restorative Bioscaffold products work in all phases of healing to stabilize, correct, build and organize tissue.Д®ndoformв„ў products are made from AROA ECMв„ў technology and contain more than 150 extracellular matrix (ECM) proteins that enable it to interact with patientвЂ™s cells throughout all phases of healing. Miller: Ionic silver functionalized ovine forestomach matrix вЂ“ a non-cytotoxic antimicrobial biomaterial for tissue regeneration applications.

Bohn: Endoform: A Simple Tool to Assess Wound Proteases. May: Functional Insights from the Proteomic Inventory of Ovine Forestomach Matrix. May: A functional extracellular matrix biomaterial derived from ovine forestomach. Hartman: Proactive and Early Aggressive Wound Management: A Shift in Strategy Developed by a Consensus Panel Examining the Current Science, Prevention, and Management of Acute and Chronic Wounds. Clinical studies to evaluate reduction in infection have not been performed.ДЎ. Reduction in colonization or microbial growth on the device has not been shown to correlate with a reduction in infections in patients. Ionic silver have been included in the Endoformв„ў Antimicrobial to protect the device from microbial contamination. *Endoformв„ў Antimicrobial contains 0.3% ionic silver to protect the dressing from microbial colonization Provides broad spectrum antimicrobial activity for up to 7 days* (6).Endoformв„ў Antimicrobial Restorative Bioscaffold contains 0.3% ionic silver, appropriate for use in early acute and chronic wound management where there is an elevated risk of infection.

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